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Blockade of α2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic neuropathic hypersensitivity

Locus coeruleus (LC)-spinal noradrenergic projections are important to endogenous analgesic mechanisms and can be activated by local glutamate signaling in the LC. The current study examined the local glutamatergic, GABAergic, and noradrenergic influences on glutamate release in the LC and noradrene...

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Veröffentlicht in:Neurosci Lett
Hauptverfasser: Hayashida, Ken-ichiro, Kimuram, Masafumi, Eisenach, James C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960428/
https://ncbi.nlm.nih.gov/pubmed/29627342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2018.04.011
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