Fibroblast Growth Factor Receptor Inhibition induces loss of matrix MCL1 and necrosis in Cholangiocarcinoma

BACKGROUND & AIMS: Myeloid cell leukemia1 (MCL1), a prosurvival member of the BCL2 protein family, plays a pivotal role in human cholangiocarcinoma (CCA) cell survival. We have previously reported that fibroblast growth factor receptor (FGFR) signaling mediates MCL1-dependent survival of CCA cel...

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Udgivet i:J Hepatol
Main Authors: Kabashima, Ayano, Hirsova, Petra, Bronk, Steven F., Hernandez, Matthew C., Truty, Mark J., Ilyas, Sumera I., Kaufmann, Scott H., Gores, Gregory J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960421/
https://ncbi.nlm.nih.gov/pubmed/29408314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2018.01.026
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