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Fibroblast Growth Factor Receptor Inhibition induces loss of matrix MCL1 and necrosis in Cholangiocarcinoma

BACKGROUND & AIMS: Myeloid cell leukemia1 (MCL1), a prosurvival member of the BCL2 protein family, plays a pivotal role in human cholangiocarcinoma (CCA) cell survival. We have previously reported that fibroblast growth factor receptor (FGFR) signaling mediates MCL1-dependent survival of CCA cel...

詳細記述

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書誌詳細
出版年:J Hepatol
主要な著者: Kabashima, Ayano, Hirsova, Petra, Bronk, Steven F., Hernandez, Matthew C., Truty, Mark J., Ilyas, Sumera I., Kaufmann, Scott H., Gores, Gregory J.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960421/
https://ncbi.nlm.nih.gov/pubmed/29408314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2018.01.026
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