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An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP

The high fidelity of DNA replication and repair is attributable, in part, to the allosteric regulation of ribonucleotide reductases (RNRs) that maintains proper deoxynucleotide pool sizes and ratios in vivo. In class Ia RNRs, ATP (stimulatory) and dATP (inhibitory) regulate activity by binding to th...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Parker, Mackenzie J., Maggiolo, Ailiena O., Thomas, William C., Kim, Albert, Meisburger, Steve P., Ando, Nozomi, Boal, Amie K., Stubbe, JoAnne
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960316/
https://ncbi.nlm.nih.gov/pubmed/29712847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800356115
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