Distinct gating mechanism of SOC channel involving STIM–Orai coupling and an intramolecular interaction of Orai in Caenorhabditis elegans

Store-operated calcium entry (SOCE), an important mechanism of Ca(2+) signaling in a wide range of cell types, is mediated by stromal interaction molecule (STIM), which senses the depletion of endoplasmic reticulum Ca(2+) stores and binds and activates Orai channels in the plasma membrane. This insi...

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Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Kim, Kyu Min, Wijerathne, Tharaka, Hur, Jin-Hoe, Kang, Uk Jung, Kim, Ihn Hyeong, Kweon, Yeong Cheon, Lee, Ah Reum, Jeong, Su Ji, Lee, Sang Kwon, Lee, Yoon Young, Sim, Bo-Woong, Lee, Jong-Hee, Baig, Chunggi, Kim, Sun-Uk, Chang, Kyu-Tae, Lee, Kyu Pil, Park, Chan Young
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2018
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PNAS Plus
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960282/
https://ncbi.nlm.nih.gov/pubmed/29712850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714986115
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