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Network-Based Analysis of Bortezomib Pharmacodynamic Heterogeneity in Multiple Myeloma Cells

The objective of this study is to evaluate the heterogeneity in pharmacodynamic response in four in vitro multiple myeloma cell lines to treatment with bortezomib, and to assess whether such differences are associated with drug-induced intracellular signaling protein dynamics identified via a logic-...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Ramakrishnan, Vidya, Mager, Donald E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959840/
https://ncbi.nlm.nih.gov/pubmed/29632237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.247924
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