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Sequential Exposure of Bortezomib and Vorinostat is Synergistic in Multiple Myeloma Cells

PURPOSE: To examine the combination of bortezomib and vorinostat in multiple myeloma cells (U266) and xenografts, and to assess the nature of their potential interactions with semi-mechanistic pharmacodynamic models and biomarkers. METHODS: U266 proliferation was examined for a range of bortezomib a...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Nanavati, Charvi, Mager, Donald E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826571/
https://ncbi.nlm.nih.gov/pubmed/28101809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-017-2095-5
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