Analysis of the Pseudouridimycin Biosynthetic Pathway Provides Insights into the Formation of C-nucleoside Antibiotics

Pseudouridimycin (PUM) is a selective nucleosideanalog inhibitor of bacterial RNA polymerase with activity against Gram-positive and Gram-negative bacteria. PUM, produced by Streptomyces sp. ID38640, consists of a formamidinylated, N-hydroxylated Gly- Gln dipeptide conjugated to 5′-aminopseudouridin...

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Publicado en:Cell Chem Biol
Main Authors: Sosio, Margherita, Gaspari, Eleonora, Iorio, Marianna, Pessina, Silvia, Medema, Marnix H., Bernasconi, Alice, Simone, Matteo, Maffioli, Sonia I., Ebright, Richard H., Donadio, Stefano
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959762/
https://ncbi.nlm.nih.gov/pubmed/29551347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.02.008
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