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Analysis of the Pseudouridimycin Biosynthetic Pathway Provides Insights into the Formation of C-nucleoside Antibiotics
Pseudouridimycin (PUM) is a selective nucleosideanalog inhibitor of bacterial RNA polymerase with activity against Gram-positive and Gram-negative bacteria. PUM, produced by Streptomyces sp. ID38640, consists of a formamidinylated, N-hydroxylated Gly- Gln dipeptide conjugated to 5′-aminopseudouridin...
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| Publicado no: | Cell Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5959762/ https://ncbi.nlm.nih.gov/pubmed/29551347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.02.008 |
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