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Prp8 positioning of U5 snRNA is linked to 5′ splice site recognition
Prp8 is an essential protein that regulates spliceosome assembly and conformation during pre-mRNA splicing. Recent cryo-EM structures of the spliceosome model Prp8 as a scaffold for the spliceosome's catalytic U snRNA components. Using a new amino acid probing strategy, we identified a dynamic...
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| Publicat a: | RNA |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5959246/ https://ncbi.nlm.nih.gov/pubmed/29487104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.065458.117 |
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