Prp8 positioning of U5 snRNA is linked to 5′ splice site recognition

Prp8 is an essential protein that regulates spliceosome assembly and conformation during pre-mRNA splicing. Recent cryo-EM structures of the spliceosome model Prp8 as a scaffold for the spliceosome's catalytic U snRNA components. Using a new amino acid probing strategy, we identified a dynamic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:RNA
Prif Awduron: MacRae, Andrew J., Mayerle, Megan, Hrabeta-Robinson, Eva, Chalkley, Robert J., Guthrie, Christine, Burlingame, Alma L., Jurica, Melissa S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2018
Pynciau:
Report
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959246/
https://ncbi.nlm.nih.gov/pubmed/29487104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.065458.117
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