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Prp8 positioning of U5 snRNA is linked to 5′ splice site recognition
Prp8 is an essential protein that regulates spliceosome assembly and conformation during pre-mRNA splicing. Recent cryo-EM structures of the spliceosome model Prp8 as a scaffold for the spliceosome's catalytic U snRNA components. Using a new amino acid probing strategy, we identified a dynamic...
Gorde:
| Argitaratua izan da: | RNA |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Cold Spring Harbor Laboratory Press
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5959246/ https://ncbi.nlm.nih.gov/pubmed/29487104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.065458.117 |
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