Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates

Sphingosine-1-phosphate (S1P) plays important roles in cardiovascular development and immunity. S1P is abundant in plasma because erythrocytes—the major source of S1P—lack any S1P-degrading activity; however, much remains unclear about the source of the plasma S1P precursor, sphingosine (SPH), deriv...

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Udgivet i:FASEB J
Main Authors: Li, Fang, Xu, Ruijuan, Low, Benjamin E., Lin, Chih-Li, Garcia-Barros, Monica, Schrandt, Jennifer, Mileva, Izolda, Snider, Ashley, Luo, Catherine K., Jiang, Xian-Cheng, Li, Ming-Song, Hannun, Yusuf A., Obeid, Lina M., Wiles, Michael V., Mao, Cungui
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5956249/
https://ncbi.nlm.nih.gov/pubmed/29401619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700445RR
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