Disruption of Wnt/β-catenin exerts anti-leukemia activity and synergizes with FLT3 inhibition in FLT3-mutant acute myeloid leukemia

PURPOSE: Wnt/β-catenin signaling is required for leukemic stem cell function. FLT3 mutations are frequently observed in acute myeloid leukemia (AML). Anomalous FLT3 signaling increases β-catenin nuclear localization and transcriptional activity. FLT3 tyrosine kinase inhibitors (TKIs) are used clinic...

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Pubblicato in:Clin Cancer Res
Autori principali: Jiang, Xuejie, Mak, Po Yee, Mu, Hong, Tao, Wenjing, Mak, Duncan H, Kornblau, Steven, Zhang, Qi, Ruvolo, Peter, Burks, Jared K, Zhang, Weiguo, McQueen, Teresa, Pan, Rongqing, Zhou, Hongsheng, Konopleva, Marina, Cortes, Jorge, Liu, Qifa, Andreeff, Michael, Carter, Bing Z
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955840/
https://ncbi.nlm.nih.gov/pubmed/29463558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1556
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