OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia

Internal tandem duplication (-ITD) mutations of Fms-like tyrosine kinase 3 (FLT3) provide growth and pro-survival signals in the context of established driver mutations in FLT3 mutant acute myeloid leukemia (AML). Maternal embryonic leucine zipper kinase (MELK) is an aberrantly expressed gene identi...

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Udgivet i:Blood Cancer J
Main Authors: Eisfelder, Bartholomew J., Saygin, Caner, Wynne, Joseph, Colton, Margaret W., Fischietti, Mariafausta, Beauchamp, Elspeth M., Cheng, Jason X., Odenike, Olatoyosi, Roboz, Gail, Alachkar, Houda, Stock, Wendy
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930094/
https://ncbi.nlm.nih.gov/pubmed/33658483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-021-00433-3
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