High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C. elegans SC_APP Model

The nematode Caenorhabditis elegans, with tractable genetics and a well-defined nervous system, provides a unique whole-animal model system to identify novel drug targets and therapies for neurodegenerative diseases. Large-scale drug or target screens in models that recapitulate the subtle age- and...

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Pubblicato in:ACS Chem Neurosci
Autori principali: Monda, Sudip, Hegarty, Evan, Sahn, James J., Scott, Luisa L., Gökçe, Sertan Kutal, Martin, Chris, Ghorashian, Navid, Satarasinghe, Praveen Navoda, Iyer, Sangeetha, Sae-Lee, Wisath, Hodges, Timothy R., Pierce, Jonathan T., Martin, Stephen F., Ben-Yakar, Adela
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955835/
https://ncbi.nlm.nih.gov/pubmed/29426225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00428
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