STIM2-mediated Increase in Resting [Ca(2+)](cyt) Stimulates PASMC Proliferation in Pulmonary Arterial Hypertension

An increase in cytosolic Ca(2+) concentration ([Ca(2+)](cyt)) in pulmonary artery smooth muscle cells (PASMCs) triggers pulmonary vasoconstriction and stimulates PASMC proliferation leading to vascular wall thickening. Here, we report that STIM2, a Ca(2+) sensor in the sarcoplasmic reticulum (SR) me...

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Detalhes bibliográficos
Publicado no:Hypertension
Main Authors: Song, Shanshan, Carr, Shane G., McDermott, Kimberly M., Rodriguez, Marisela, Babicheva, Aleksandra, Balistrieri, Angela, Ayon, Ramon J., Wang, Jian, Makino, Ayako, Yuan, Jason X.-J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955710/
https://ncbi.nlm.nih.gov/pubmed/29358461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10503
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