Oncodriver inhibition and CD4(+) Th1 cytokines cooperate through Stat1 activation to induce tumor senescence and apoptosis in HER2+ and triple negative breast cancer: implications for combining immune and targeted therapies

In patients with HER2-expressing breast cancer many develop resistance to HER2 targeted therapies. We show that high and intermediate HER2-expressing cancer cell lines are driven toward apoptosis and tumor senescence when treated with either CD4(+) Th1 cells, or Th1 cytokines TNF-α and IFN-γ, in a d...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Rosemblit, Cinthia, Datta, Jashodeep, Lowenfeld, Lea, Xu, Shuwen, Basu, Amrita, Kodumudi, Krithika, Wiener, Doris, Czerniecki, Brian J.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2018
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955413/
https://ncbi.nlm.nih.gov/pubmed/29796172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25208
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