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CD4(+) Th1 to the rescue in HER-2+ breast cancer
HER2 overexpression leads to downregulation of MHC class-I. CD4(+) Th1 cytokines, IFNγ and TNFα, and monoclonal antibodies, trastuzumab and pertuzumab, restore MHC class-I expression, and enable CD8(+) recognition and cytolysis. Restoration of the anti-HER2 CD4(+) Th1 immune response in combination...
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| Udgivet i: | Oncoimmunology |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6791441/ https://ncbi.nlm.nih.gov/pubmed/31646065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1078062 |
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