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A straightforward method for automated Fmoc-based synthesis of bio-inspired peptide crypto-thioesters
Despite recent advances, the direct Fmoc-based solid phase synthesis of peptide α-thioesters for the convergent synthesis of proteins via native chemical ligation (NCL) remains a challenge in the field. We herein report a simple and general methodology, enabling access to peptide thioester surrogate...
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| Veröffentlicht in: | Chem Sci |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Royal Society of Chemistry
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5952550/ https://ncbi.nlm.nih.gov/pubmed/29861986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc02630j |
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