Efficient Chemical Protein Synthesis using Fmoc‐Masked N‐Terminal Cysteine in Peptide Thioester Segments

We report an operationally simple method to facilitate chemical protein synthesis by fully convergent and one‐pot native chemical ligations utilizing the fluorenylmethyloxycarbonyl (Fmoc) moiety as an N‐masking group of the N‐terminal cysteine of the middle peptide thioester segment(s). The Fmoc gro...

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Publicado en:Angew Chem Int Ed Engl
Autores principales: Kar, Abhisek, Mannuthodikayil, Jamsad, Singh, Sameer, Biswas, Anamika, Dubey, Puneet, Das, Amit, Mandal, Kalyaneswar
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7891605/
https://ncbi.nlm.nih.gov/pubmed/32333711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202000491
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