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A Reversible Protection Strategy to Improve Fmoc-SPPS of Peptide Thioesters by the N-Acylurea Approach

C-terminal peptide thioesters are an essential component of the native chemical ligation approach for the preparation of fully- or semi-synthetic proteins. However, efficient generation of C-terminal thioesters via Fmoc solid phase peptide synthesis remains a challenge. The recent N-acylurea approac...

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Main Authors: Mahto, Santosh K., Howard, Cecil J., Shimko, John C., Ottesen, Jennifer J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558277/
https://ncbi.nlm.nih.gov/pubmed/21910203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201100472
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