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Synthesis of protected norcysteines for SPPS compatible with Fmoc-strategy

We report the synthesis of racemic Alloc-Ncy(Tmob)-OH, the resolution of its methyl ester, and demonstrate its application to form a norcystine bridge in octreotide-amide using the Fmoc-strategy on solid phase. N-Alloc and S-Tmob protections of norcysteine (Ncy) were found to be a preferred choice f...

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Detalhes bibliográficos
Main Authors: Samant, Manoj P., Rivier, Jean E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701708/
https://ncbi.nlm.nih.gov/pubmed/19562100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2007.05.082
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