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Scope & Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin

We have systematically explored three approaches based on Fmoc chemistry SPPS for the total chemical synthesis of the key depsipeptide intermediate for the efficient total chemical synthesis of insulin. The approaches used were: stepwise Fmoc chemistry SPPS; the ‘hybrid method’, in which maximally-p...

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書誌詳細
出版年:Chemistry
主要な著者: Dhayalan, Balamurugan, Mandal, Kalyaneswar, Rege, Nischay, Weiss, Michael A., Eitel, Simon H., Meier, Thomas, Schoenleber, Ralph O., Kent, Stephen B.H.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636692/
https://ncbi.nlm.nih.gov/pubmed/27905149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201605578
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