Scope & Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin

We have systematically explored three approaches based on Fmoc chemistry SPPS for the total chemical synthesis of the key depsipeptide intermediate for the efficient total chemical synthesis of insulin. The approaches used were: stepwise Fmoc chemistry SPPS; the ‘hybrid method’, in which maximally-p...

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Détails bibliographiques
Publié dans:Chemistry
Auteurs principaux: Dhayalan, Balamurugan, Mandal, Kalyaneswar, Rege, Nischay, Weiss, Michael A., Eitel, Simon H., Meier, Thomas, Schoenleber, Ralph O., Kent, Stephen B.H.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636692/
https://ncbi.nlm.nih.gov/pubmed/27905149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201605578
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