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Direct Fmoc-Chemistry-Based Solid Phase Synthesis of Peptidyl Thioesters

[Image: see text] Attachment of a growing peptide chain to a glycylaminomethyl resin via a thioglycinamide bond is compatible with Fmoc-chemistry solid phase peptide synthesis. Subsequent S-alkylation of the thioamide gives a thioimide which, on treatment with aqueous trifluoroacetic acid releases t...

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Bibliografiske detaljer
Main Authors: Sharma, Indrajeet, Crich, David
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184774/
https://ncbi.nlm.nih.gov/pubmed/21718046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo200497j
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