High‐throughput discovery of functional disordered regions: investigation of transactivation domains

Over 40% of proteins in any eukaryotic genome encode intrinsically disordered regions (IDRs) that do not adopt defined tertiary structures. Certain IDRs perform critical functions, but discovering them is non‐trivial as the biological context determines their function. We present IDR‐Screen, a frame...

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Vydáno v:Mol Syst Biol
Hlavní autoři: Ravarani, Charles NJ, Erkina, Tamara Y, De Baets, Greet, Dudman, Daniel C, Erkine, Alexandre M, Babu, M Madan
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949888/
https://ncbi.nlm.nih.gov/pubmed/29759983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20188190
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