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High‐throughput discovery of functional disordered regions: investigation of transactivation domains

Over 40% of proteins in any eukaryotic genome encode intrinsically disordered regions (IDRs) that do not adopt defined tertiary structures. Certain IDRs perform critical functions, but discovering them is non‐trivial as the biological context determines their function. We present IDR‐Screen, a frame...

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Bibliografiske detaljer
Udgivet i:Mol Syst Biol
Main Authors: Ravarani, Charles NJ, Erkina, Tamara Y, De Baets, Greet, Dudman, Daniel C, Erkine, Alexandre M, Babu, M Madan
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949888/
https://ncbi.nlm.nih.gov/pubmed/29759983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20188190
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