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High‐throughput discovery of functional disordered regions: investigation of transactivation domains

Over 40% of proteins in any eukaryotic genome encode intrinsically disordered regions (IDRs) that do not adopt defined tertiary structures. Certain IDRs perform critical functions, but discovering them is non‐trivial as the biological context determines their function. We present IDR‐Screen, a frame...

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Detalhes bibliográficos
Publicado no:Mol Syst Biol
Main Authors: Ravarani, Charles NJ, Erkina, Tamara Y, De Baets, Greet, Dudman, Daniel C, Erkine, Alexandre M, Babu, M Madan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949888/
https://ncbi.nlm.nih.gov/pubmed/29759983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20188190
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