Distinct stimulatory mechanisms regulate the catalytic activity of Polycomb Repressive Complex 2 (PRC2)

The maintenance of gene expression patterns during metazoan development is achieved, in part, by the actions of Polycomb Repressive Complex 2 (PRC2). PRC2 catalyzes mono-, di- and trimethylation of histone H3 at lysine 27 (H3K27), with H3K27me2/3 being strongly associated with silenced genes. We dem...

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Udgivet i:Mol Cell
Main Authors: Lee, Chul-Hwan, Holder, Marlene, Grau, Daniel, Saldaña-Meyer, Ricardo, Yu, Jia-Ray, Ganai, Rais Ahmad, Zhang, Jenny, Wang, Miao, LeRoy, Gary, Dobenecker, Marc-Werner, Reinberg, Danny, Armache, Karim-Jean
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949877/
https://ncbi.nlm.nih.gov/pubmed/29681498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.03.019
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