Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction

Polycomb repressive complex 2 (PRC2) is a histone methyltransferase critical for maintaining gene silencing during eukaryotic development. In mammals, PRC2 activity is regulated in part by the selective incorporation of one of two paralogs of the catalytic subunit, EZH1 or EZH2. Each of these enzyme...

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Publicat a:Nat Commun
Autors principals: Grau, Daniel, Zhang, Yixiao, Lee, Chul-Hwan, Valencia-Sánchez, Marco, Zhang, Jenny, Wang, Miao, Holder, Marlene, Svetlov, Vladimir, Tan, Dongyan, Nudler, Evgeny, Reinberg, Danny, Walz, Thomas, Armache, Karim-Jean
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846606/
https://ncbi.nlm.nih.gov/pubmed/33514705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20775-z
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