Complex Landscape of Germline Variants in Brazilian Patients With Hereditary and Early Onset Breast Cancer

Pathogenic variants in known breast cancer (BC) predisposing genes explain only about 30% of Hereditary Breast Cancer (HBC) cases, whereas the underlying genetic factors for most families remain unknown. Here, we used whole-exome sequencing (WES) to identify genetic variants associated to HBC in 17...

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Podrobná bibliografie
Vydáno v:Front Genet
Hlavní autoři: Torrezan, Giovana T., de Almeida, Fernanda G. dos Santos R., Figueiredo, Márcia C. P., Barros, Bruna D. de Figueiredo, de Paula, Cláudia A. A., Valieris, Renan, de Souza, Jorge E. S., Ramalho, Rodrigo F., da Silva, Felipe C. C., Ferreira, Elisa N., de Nóbrega, Amanda F., Felicio, Paula S., Achatz, Maria I., de Souza, Sandro J., Palmero, Edenir I., Carraro, Dirce M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949367/
https://ncbi.nlm.nih.gov/pubmed/29868112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00161
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