Complex Landscape of Germline Variants in Brazilian Patients With Hereditary and Early Onset Breast Cancer

Pathogenic variants in known breast cancer (BC) predisposing genes explain only about 30% of Hereditary Breast Cancer (HBC) cases, whereas the underlying genetic factors for most families remain unknown. Here, we used whole-exome sequencing (WES) to identify genetic variants associated to HBC in 17...

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發表在:Front Genet
Main Authors: Torrezan, Giovana T., de Almeida, Fernanda G. dos Santos R., Figueiredo, Márcia C. P., Barros, Bruna D. de Figueiredo, de Paula, Cláudia A. A., Valieris, Renan, de Souza, Jorge E. S., Ramalho, Rodrigo F., da Silva, Felipe C. C., Ferreira, Elisa N., de Nóbrega, Amanda F., Felicio, Paula S., Achatz, Maria I., de Souza, Sandro J., Palmero, Edenir I., Carraro, Dirce M.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2018
主題:
Genetics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949367/
https://ncbi.nlm.nih.gov/pubmed/29868112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00161
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