Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice

T-cell activation is characteristic during the development of atherosclerosis. While overall T-cell responses have been implicated in disease acceleration, regulatory T cells (Tregs) exhibit atheroprotective effects. The expression of the enzyme indoleamine 2,3-dioxygenase-1 (IDO1), which catalyzes...

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Bibliografische gegevens
Gepubliceerd in:Front Immunol
Hoofdauteurs: Forteza, Maria J., Polyzos, Konstantinos A., Baumgartner, Roland, Suur, Bianca E., Mussbacher, Marion, Johansson, Daniel K., Hermansson, Andreas, Hansson, Göran K., Ketelhuth, Daniel F. J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2018
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949314/
https://ncbi.nlm.nih.gov/pubmed/29867939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00950
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