3-Hydroxyanthralinic acid metabolism controls the hepatic SREBP/lipoprotein axis, inhibits inflammasome activation in macrophages, and decreases atherosclerosis in Ldlr(−/−) mice

AIMS: Atherosclerosis is a chronic inflammatory disease involving immunological and metabolic processes. Metabolism of tryptophan (Trp) via the kynurenine pathway has shown immunomodulatory properties and the ability to modulate atherosclerosis. We identified 3-hydroxyanthranilic acid (3-HAA) as a k...

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Vydáno v:Cardiovasc Res
Hlavní autoři: Berg, Martin, Polyzos, Konstantinos A, Agardh, Hanna, Baumgartner, Roland, Forteza, Maria J, Kareinen, Ilona, Gisterå, Anton, Bottcher, Gerhard, Hurt-Camejo, Eva, Hansson, Göran K, Ketelhuth, Daniel F J
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519886/
https://ncbi.nlm.nih.gov/pubmed/31589306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvz258
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