Genetic Deficiency of Indoleamine 2,3-dioxygenase Aggravates Vascular but Not Liver Disease in a Nonalcoholic Steatohepatitis and Atherosclerosis Comorbidity Model

Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that increases cardiovascular disease risk. Indoleamine 2,3-dioxygenase-1 (IDO1)-mediated tryptophan (Trp) metabolism has been proposed to play an immunomodulatory role in several diseases. The potential of IDO1 to be a link between NASH...

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Main Authors: Aastha Arora, Gustavo Luis Tripodi, Ilona Kareinen, Martin Berg, Maria Josefa Forteza, Anton Gisterå, Silke Griepke, Felipe Beccaria Casagrande, Joilson O. Martins, Dulcineia Saes Parra Abdalla, Jennifer Cole, Claudia Monaco, Daniel F. J. Ketelhuth
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-05-01
Colecção:International Journal of Molecular Sciences
Assuntos:
IDO
inflammation
atherosclerosis
NASH
immunometabolism
Acesso em linha:https://www.mdpi.com/1422-0067/23/9/5203
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