Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses

CD58 is an adhesion molecule that is known to play a critical role in costimulation of effector cells and is intrinsic to immune synapse structure. Herein, we describe a virally encoded gene that inhibits CD58 surface expression. Human cytomegalovirus (HCMV) UL148 was necessary and sufficient to pro...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Wang, Eddie C. Y., Pjechova, Mariana, Nightingale, Katie, Vlahava, Virginia-Maria, Patel, Mihil, Ruckova, Eva, Forbes, Simone K., Nobre, Luis, Antrobus, Robin, Roberts, Dawn, Fielding, Ceri A., Seirafian, Sepehr, Davies, James, Murrell, Isa, Lau, Betty, Wilkie, Gavin S., Suárez, Nicolás M., Stanton, Richard J., Vojtesek, Borivoj, Davison, Andrew, Lehner, Paul J., Weekes, Michael P., Wilkinson, Gavin W. G., Tomasec, Peter
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948980/
https://ncbi.nlm.nih.gov/pubmed/29691324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720950115
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