Two Novel Human Cytomegalovirus NK Cell Evasion Functions Target MICA for Lysosomal Degradation

NKG2D plays a major role in controlling immune responses through the regulation of natural killer (NK) cells, αβ and γδ T-cell function. This activating receptor recognizes eight distinct ligands (the MHC Class I polypeptide-related sequences (MIC) A andB, and UL16-binding proteins (ULBP)1–6) induce...

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Autori principali: Fielding, Ceri A., Aicheler, Rebecca, Stanton, Richard J., Wang, Eddie C. Y., Han, Song, Seirafian, Sepehr, Davies, James, McSharry, Brian P., Weekes, Michael P., Antrobus, P. Robin, Prod'homme, Virginie, Blanchet, Fabien P., Sugrue, Daniel, Cuff, Simone, Roberts, Dawn, Davison, Andrew J., Lehner, Paul J., Wilkinson, Gavin W. G., Tomasec, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006889/
https://ncbi.nlm.nih.gov/pubmed/24787765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004058
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