Human Cytomegalovirus UL40 Signal Peptide Regulates Cell Surface Expression of the Natural Killer Cell Ligands HLA-E and gpUL18

Human cytomegalovirus (HCMV)-encoded NK cell evasion functions include an MHC-I homologue (UL18) with high affinity for the leukocyte inhibitory receptor LIR-1 (CD85j, ILT2 or LILRB1) and a signal peptide (SP(UL40)) that acts by upregulating cell surface expression of HLA-E. Detailed characterizatio...

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Hauptverfasser: Prod’homme, Virginie, Tomasec, Peter, Cunningham, Charles, Lemberg, Marius K., Stanton, Richard J., McSharry, Brian P., Wang, Eddie C.Y., Cuff, Simone, Martoglio, Bruno, Davison, Andrew J., Braud, Véronique M., Wilkinson, Gavin W. G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303119/
https://ncbi.nlm.nih.gov/pubmed/22345649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102068
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