Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112

Human cytomegalovirus (HCMV) UL141 induces protection against natural killer cell-mediated cytolysis by downregulating cell surface expression of CD155 (nectin-like molecule 5; poliovirus receptor), a ligand for the activating receptor DNAM-1 (CD226). However, DNAM-1 is also recognized to bind a sec...

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Main Authors: Prod'homme, Virginie, Sugrue, Daniel M., Stanton, Richard J., Nomoto, Akio, Davies, James, Rickards, Carole R., Cochrane, Daniel, Moore, Melanie, Wilkinson, Gavin W. G., Tomasec, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Society for General Microbiology 2010
Fag:
Animal
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052539/
https://ncbi.nlm.nih.gov/pubmed/20410314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.021931-0
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