Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses

CD58 is an adhesion molecule that is known to play a critical role in costimulation of effector cells and is intrinsic to immune synapse structure. Herein, we describe a virally encoded gene that inhibits CD58 surface expression. Human cytomegalovirus (HCMV) UL148 was necessary and sufficient to pro...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Wang, Eddie C. Y., Pjechova, Mariana, Nightingale, Katie, Vlahava, Virginia-Maria, Patel, Mihil, Ruckova, Eva, Forbes, Simone K., Nobre, Luis, Antrobus, Robin, Roberts, Dawn, Fielding, Ceri A., Seirafian, Sepehr, Davies, James, Murrell, Isa, Lau, Betty, Wilkie, Gavin S., Suárez, Nicolás M., Stanton, Richard J., Vojtesek, Borivoj, Davison, Andrew, Lehner, Paul J., Weekes, Michael P., Wilkinson, Gavin W. G., Tomasec, Peter
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2018
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948980/
https://ncbi.nlm.nih.gov/pubmed/29691324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720950115
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