Genetic Stability of Bacterial Artificial Chromosome-Derived Human Cytomegalovirus during Culture In Vitro

Clinical human cytomegalovirus (HCMV) strains invariably mutate when propagated in vitro. Mutations in gene RL13 are selected in all cell types, whereas in fibroblasts mutants in the UL128 locus (UL128L; genes UL128, UL130, and UL131A) are also selected. In addition, sporadic mutations are selected...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Murrell, Isa, Wilkie, Gavin S., Davison, Andrew J., Statkute, Evelina, Fielding, Ceri A., Tomasec, Peter, Wilkinson, Gavin W. G., Stanton, Richard J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Genetic Diversity and Evolution
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810542/
https://ncbi.nlm.nih.gov/pubmed/26842472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02858-15
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