Genetic Stability of Bacterial Artificial Chromosome-Derived Human Cytomegalovirus during Culture In Vitro

Clinical human cytomegalovirus (HCMV) strains invariably mutate when propagated in vitro. Mutations in gene RL13 are selected in all cell types, whereas in fibroblasts mutants in the UL128 locus (UL128L; genes UL128, UL130, and UL131A) are also selected. In addition, sporadic mutations are selected...

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Vydáno v:J Virol
Hlavní autoři: Murrell, Isa, Wilkie, Gavin S., Davison, Andrew J., Statkute, Evelina, Fielding, Ceri A., Tomasec, Peter, Wilkinson, Gavin W. G., Stanton, Richard J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Genetic Diversity and Evolution
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810542/
https://ncbi.nlm.nih.gov/pubmed/26842472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02858-15
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