Molecular mechanism to recruit galectin-3 into multivesicular bodies for polarized exosomal secretion

The beta-galactoside binding lectin galectin-3 (Gal3) is found intracellularly and in the extracellular space. Secretion of this lectin is mediated independently of the secretory pathway by a not yet defined nonclassical mechanism. Here, we found Gal3 in the lumen of exosomes. Superresolution and el...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Bänfer, Sebastian, Schneider, Dominik, Dewes, Jenny, Strauss, Maximilian T., Freibert, Sven-A., Heimerl, Thomas, Maier, Uwe G., Elsässer, Hans-Peter, Jungmann, Ralf, Jacob, Ralf
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948969/
https://ncbi.nlm.nih.gov/pubmed/29686075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718921115
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