Seizure-Suppressant and Neuroprotective Effects of Encapsulated BDNF-Producing Cells in a Rat Model of Temporal Lobe Epilepsy

Brain-derived neurotrophic factor (BDNF) may represent a therapeutic for chronic epilepsy, but evaluating its potential is complicated by difficulties in its delivery to the brain. Here, we describe the effects on epileptic seizures of encapsulated cell biodelivery (ECB) devices filled with genetica...

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Bibliografiske detaljer
Udgivet i:Mol Ther Methods Clin Dev
Main Authors: Falcicchia, Chiara, Paolone, Giovanna, Emerich, Dwaine F., Lovisari, Francesca, Bell, William J., Fradet, Tracie, Wahlberg, Lars U., Simonato, Michele
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948312/
https://ncbi.nlm.nih.gov/pubmed/29766029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.03.001
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