Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy

Neurotrophic factors are candidates for treating epilepsy, but their development has been hampered by difficulties in achieving stable and targeted delivery of efficacious concentrations within the desired brain region. We have developed an encapsulated cell technology that overcomes these obstacles...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Paolone, Giovanna, Falcicchia, Chiara, Lovisari, Francesca, Kokaia, Merab, Bell, William J., Fradet, Tracie, Barbieri, Mario, Wahlberg, Lars U., Emerich, Dwaine F., Simonato, Michele
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2019
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6507083/
https://ncbi.nlm.nih.gov/pubmed/30665947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0435-18.2018
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