X-ray and cryo-EM structures of inhibitor-bound cytochrome bc (1) complexes for structure-based drug discovery

Cytochrome bc (1), a dimeric multi-subunit electron-transport protein embedded in the inner mitochondrial membrane, is a major drug target for the treatment and prevention of malaria and toxoplasmosis. Structural studies of cytochrome bc (1) from mammalian homologues co-crystallized with lead compou...

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Detalhes bibliográficos
Publicado no:IUCrJ
Main Authors: Amporndanai, Kangsa, Johnson, Rachel M., O’Neill, Paul M., Fishwick, Colin W. G., Jamson, Alexander H., Rawson, Shaun, Muench, Stephen P., Hasnain, S. Samar, Antonyuk, Svetlana V.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5947725/
https://ncbi.nlm.nih.gov/pubmed/29765610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252518001616
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