Antimalarial 4(1H)-pyridones bind to the Q(i) site of cytochrome bc(1)

Cytochrome bc(1) is a proven drug target in the prevention and treatment of malaria. The rise in drug-resistant strains of Plasmodium falciparum, the organism responsible for malaria, has generated a global effort in designing new classes of drugs. Much of the design/redesign work on overcoming this...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Capper, Michael J., O’Neill, Paul M., Fisher, Nicholas, Strange, Richard W., Moss, Darren, Ward, Stephen A., Berry, Neil G., Lawrenson, Alexandre S., Hasnain, S. Samar, Biagini, Giancarlo A., Antonyuk, Svetlana V.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311836/
https://ncbi.nlm.nih.gov/pubmed/25564664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416611112
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