Antimalarial 4(1H)-pyridones bind to the Q(i) site of cytochrome bc(1)

Cytochrome bc(1) is a proven drug target in the prevention and treatment of malaria. The rise in drug-resistant strains of Plasmodium falciparum, the organism responsible for malaria, has generated a global effort in designing new classes of drugs. Much of the design/redesign work on overcoming this...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Capper, Michael J., O’Neill, Paul M., Fisher, Nicholas, Strange, Richard W., Moss, Darren, Ward, Stephen A., Berry, Neil G., Lawrenson, Alexandre S., Hasnain, S. Samar, Biagini, Giancarlo A., Antonyuk, Svetlana V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311836/
https://ncbi.nlm.nih.gov/pubmed/25564664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416611112
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