Antimalarial 4(1H)-pyridones bind to the Q(i) site of cytochrome bc(1)

Cytochrome bc(1) is a proven drug target in the prevention and treatment of malaria. The rise in drug-resistant strains of Plasmodium falciparum, the organism responsible for malaria, has generated a global effort in designing new classes of drugs. Much of the design/redesign work on overcoming this...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Capper, Michael J., O’Neill, Paul M., Fisher, Nicholas, Strange, Richard W., Moss, Darren, Ward, Stephen A., Berry, Neil G., Lawrenson, Alexandre S., Hasnain, S. Samar, Biagini, Giancarlo A., Antonyuk, Svetlana V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2015
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311836/
https://ncbi.nlm.nih.gov/pubmed/25564664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416611112
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