Abacavir forms novel cross-linking abacavir protein adducts in patients

Por Meng, Xiaoli, Lawrenson, Alexandre, Berry, Neil, Maggs, James, French, Neil, Back, David, Khoo, Saye, Naisbitt, Dean, Park, Kevin
Publicado em 2014

HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochrome bc(1) Complex

Por Vallières, Cindy, Fisher, Nicholas, Antoine, Thomas, Al-Helal, Mohammed, Stocks, Paul, Berry, Neil G., Lawrenson, Alexandre S., Ward, Stephen A., O'Neill, Paul M., Biagini, Giancarlo A., Meunier, Brigitte
Publicado em 2012

Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc(1) Catalytic Turnover and Protein Expression

Por Fisher, Nicholas, Abd Majid, Roslaini, Antoine, Thomas, Al-Helal, Mohammed, Warman, Ashley J., Johnson, David J., Lawrenson, Alexandre S., Ranson, Hilary, O'Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.
Publicado em 2012

Antimalarial 4(1H)-pyridones bind to the Q(i) site of cytochrome bc(1)

Por Capper, Michael J., O’Neill, Paul M., Fisher, Nicholas, Strange, Richard W., Moss, Darren, Ward, Stephen A., Berry, Neil G., Lawrenson, Alexandre S., Hasnain, S. Samar, Biagini, Giancarlo A., Antonyuk, Svetlana V.
Publicado no Proc Natl Acad Sci U S A (2015)

Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD

Por Price, Kathryn E., Armstrong, Christopher M., Imlay, Leah S., Hodge, Dana M., Pidathala, C., Roberts, Natalie J., Park, Jooyoung, Mikati, Marwa, Sharma, Raman, Lawrenson, Alexandre S., Tolia, Niraj H., Berry, Neil G., O’Neill, Paul M., John, Audrey R. Odom
Publicado no Sci Rep (2016)

Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: In...

Por Sharma, Raman, Lawrenson, Alexandre S., Fisher, Nicholas E., Warman, Ashley J., Shone, Alison E., Hill, Alasdair, Mbekeani, Alison, Pidathala, Chandrakala, Amewu, Richard K., Leung, Suet, Gibbons, Peter, Hong, David W., Stocks, Paul, Nixon, Gemma L., Chadwick, James, Shearer, Joanne, Gowers, Ian, Cronk, David, Parel, Serge P., O'Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A., Berry, Neil G.
Publicado em 2012

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

Por Biagini, Giancarlo A., Fisher, Nicholas, Shone, Alison E., Mubaraki, Murad A., Srivastava, Abhishek, Hill, Alisdair, Antoine, Thomas, Warman, Ashley J., Davies, Jill, Pidathala, Chandrakala, Amewu, Richard K., Leung, Suet C., Sharma, Raman, Gibbons, Peter, Hong, David W., Pacorel, Bénédicte, Lawrenson, Alexandre S., Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Stocks, Paul A., Nixon, Gemma L., Chadwick, James, Hemingway, Janet, Delves, Michael J., Sinden, Robert E., Zeeman, Anne-Marie, Kocken, Clemens H. M., Berry, Neil G., O’Neill, Paul M., Ward, Stephen A.
Publicado em 2012