A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1

Mitogen-activated protein kinase (MAPK)-interacting kinases 1 (Mnk1) and 2 (Mnk2) modulate translation initiation through the phosphorylation of eukaryotic translation initiation factor 4E, which promotes tumorigenesis. However, Mnk1 and Mnk2 are dispensable in normal cells, suggesting that the inhi...

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Enregistré dans:
Détails bibliographiques
Publié dans:Acta Crystallogr F Struct Biol Commun
Auteurs principaux: Matsui, Yumi, Yasumatsu, Isao, Yoshida, Ken-ichi, Iimura, Shin, Ikeno, Yutaka, Nawano, Takako, Fukano, Hajime, Ubukata, Osamu, Hanzawa, Hiroyuki, Tanzawa, Fumie, Isoyama, Takeshi
Format: Artigo
Langue:Inglês
Publié: International Union of Crystallography 2018
Sujets:
Research Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5947701/
https://ncbi.nlm.nih.gov/pubmed/29497019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X18002108
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