mRNA Cap Methyltransferase, RNMT-RAM, Promotes RNA Pol II-Dependent Transcription

mRNA cap addition occurs early during RNA Pol II-dependent transcription, facilitating pre-mRNA processing and translation. We report that the mammalian mRNA cap methyltransferase, RNMT-RAM, promotes RNA Pol II transcription independent of mRNA capping and translation. In cells, sublethal suppressio...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Varshney, Dhaval, Lombardi, Olivia, Schweikert, Gabriele, Dunn, Sianadh, Suska, Olga, Cowling, Victoria H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946721/
https://ncbi.nlm.nih.gov/pubmed/29719263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.004
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