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The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway
Oncogenic signals lead to premature senescence in normal human cells causing a proliferation arrest and the elimination of these defective cells by immune cells. Oncogene‐induced senescence (OIS) prevents aberrant cell division and tumor initiation. In order to identify new regulators of OIS, we per...
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| 出版年: | Aging Cell |
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| 主要な著者: | , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2018
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5946064/ https://ncbi.nlm.nih.gov/pubmed/29446526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12736 |
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