The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway

Oncogenic signals lead to premature senescence in normal human cells causing a proliferation arrest and the elimination of these defective cells by immune cells. Oncogene‐induced senescence (OIS) prevents aberrant cell division and tumor initiation. In order to identify new regulators of OIS, we per...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Warnier, Marine, Flaman, Jean‐Michel, Chouabe, Christophe, Wiel, Clotilde, Gras, Baptiste, Griveau, Audrey, Blanc, Elena, Foy, Jean‐Philippe, Mathot, Pauline, Saintigny, Pierre, Van Coppenolle, Fabien, Vindrieux, David, Martin, Nadine, Bernard, David
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946064/
https://ncbi.nlm.nih.gov/pubmed/29446526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12736
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